Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia

@article{Quillinan2015RegionspecificRF,
  title={Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia},
  author={Nidia Quillinan and Himmat S Grewal and Guiying Deng and Kaori Shimizu and Joan C. Yonchek and Frank A Strnad and Richard J. Traystman and Paco S. Herson},
  journal={Neuroscience},
  year={2015},
  volume={284},
  pages={555-565}
}
Motor deficits are present in cardiac arrest survivors and injury to cerebellar Purkinje cells (PCs) likely contribute to impairments in motor coordination and post-hypoxic myoclonus. N-Methyl-D-aspartic acid (NMDA) receptor-mediated excitotoxicity is a well-established mechanism of cell death in several brain regions, but the role of NMDA receptors in PC injury remains understudied. Emerging data in cortical and hippocampal neurons indicate that the GluN2A-containing NMDA receptors signal to… CONTINUE READING