Region-specific proliferative response of neural progenitors to exogenous stimulation by growth factors following ischemia.

@article{Oya2008RegionspecificPR,
  title={Region-specific proliferative response of neural progenitors to exogenous stimulation by growth factors following ischemia.},
  author={Soichi Oya and Gakushi Yoshikawa and Keisuke Takai and Jun-ichi Tanaka and Shigeki Higashiyama and Nobuhito Saito and Takaaki Kirino and Nobutaka Kawahara},
  journal={Neuroreport},
  year={2008},
  volume={19 8},
  pages={805-9}
}
The most effective way to augment neural progenitor proliferation after ischemia is still unknown. We administered various agents into the rat cerebral ventricle after transient global ischemia and compared the neural progenitor response in the anterior subventricular zone (aSVZ), dentate gyrus subgranular zone, posterior periventricle, and hypothalamus. We demonstrated that cocktail administration of epidermal growth factor (EGF) and fibroblast growth factor-2 (FGF-2) remarkably increased the… CONTINUE READING

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