Region-specific onset of handling-induced changes in corticotropin-releasing factor and glucocorticoid receptor expression.

@article{Fenoglio2004RegionspecificOO,
  title={Region-specific onset of handling-induced changes in corticotropin-releasing factor and glucocorticoid receptor expression.},
  author={Kristina A. Fenoglio and Kristen L. Brunson and Sarit Avishai-Eliner and Y Chen and Tallie Z. Baram},
  journal={Endocrinology},
  year={2004},
  volume={145 6},
  pages={
          2702-6
        }
}
Early-life experience including maternal care profoundly influences hormonal stress responses during adulthood. Daily handling on postnatal day (P) 2-9, eliciting augmented maternal care upon returning pups to their cage, permanently modifies the expression of the stress neuromodulators corticotropin-releasing factor (CRF) and glucocorticoid receptor (GR). We have previously demonstrated reduced hypothalamic CRF expression already at the end of the handling period, followed by enhanced… CONTINUE READING

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