Region-specific neuroprotective effect of ZM 241385 towards glutamate uptake inhibition in cultured neurons.

@article{Pepponi2009RegionspecificNE,
  title={Region-specific neuroprotective effect of ZM 241385 towards glutamate uptake inhibition in cultured neurons.},
  author={Rita Pepponi and Antonella Ferrante and Roberta Ferretti and Alberto Martire and Patrizia Popoli},
  journal={European journal of pharmacology},
  year={2009},
  volume={617 1-3},
  pages={28-32}
}
Active uptake by neurons and glial cells is the main mechanism for maintaining extracellular glutamate at low, non-toxic concentrations. Adenosine A(2A) receptors regulate extracellular glutamate levels by acting on both the release and the uptake of glutamate. The aim of this study was to evaluate whether the inhibition of the effects of glutamate uptake blockers by adenosine A(2A) receptor antagonists resulted in neuroprotection. In cortical and striatal neuronal cultures, the application of… CONTINUE READING