Region specific distribution of levomepromazine in the human brain

  title={Region specific distribution of levomepromazine in the human brain},
  author={J. Kornhuber and H. Weigmann and J. R{\"o}hrich and J. Wiltfang and S. Bleich and I. Meineke and R. Z{\"o}chling and S. H{\"a}rtter and P. Riederer and C. Hiemke},
  journal={Journal of Neural Transmission},
Summary.Objective: The aim of this study was to examine concentrations of levomepromazine and its metabolite desmethyl-levomepromazine in different regions of human brain and in relationship to drug-free time.Methods: Drug concentrations were measured in up to 43 regions of 5 postmortem human brains of patients previously treated with levomepromazine. To enable statistical comparison across brain regions several smaller brain areas were put together to form larger brain areas (cortex cerebri… Expand
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