Region-specific distribution of β-amyloid peptide and cytokine expression in TgCRND8 mice.

@article{Ma2011RegionspecificDO,
  title={Region-specific distribution of β-amyloid peptide and cytokine expression in TgCRND8 mice.},
  author={Keran Ma and Howard T. J. Mount and JoAnne McLaurin},
  journal={Neuroscience letters},
  year={2011},
  volume={492 1},
  pages={5-10}
}
Alzheimer's disease (AD) is a multifactorial disease that results in progressive neurodegeneration. Brain regions are differentially affected in AD. There is also an age-dependent effect on amyloid-beta peptide (Aβ) accumulation and neuroinflammation as disease progresses. In the TgCRND8 APP transgenic mouse model, levels of Aβ species and cytokines were examined as a function of brain region and age. A temporal sequence was observed whereby Aβ accumulation is followed by expression of IL-1… CONTINUE READING
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