Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain.

@article{Renfranz1991RegionspecificDO,
  title={Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain.},
  author={Patricia J Renfranz and Miles Gregory Cunningham and R D G Mckay},
  journal={Cell},
  year={1991},
  volume={66 4},
  pages={713-29}
}
Proliferating precursors to the distinct cell types constituting the mammalian brain can be identified by the presence of the nestin intermediate filament. We report the establishment of a nestin-positive cell line, HiB5, from embryonic precursor cells to the rat hippocampus. Since it was immortalized using the temperature-sensitive allele tsA58 of SV40 large T antigen, these cells grow continuously at 33 degrees C, but not at 39 degrees C, the body temperature of rodents. To test their… CONTINUE READING
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