Region-specific DNA damage by AT-specific DNA-reactive drugs is predicted by drug binding specificity.

@article{Woynarowski2000RegionspecificDD,
  title={Region-specific DNA damage by AT-specific DNA-reactive drugs is predicted by drug binding specificity.},
  author={Jan M. Woynarowski and Cheryl Napier and A. Vargas Trevino and Brenda Arnett},
  journal={Biochemistry},
  year={2000},
  volume={39 32},
  pages={9917-27}
}
Bizelesin and adozelesin are DNA-reactive antitumor drugs that alkylate adenines at the 3' ends of their preferred binding sites [5'T(A/T)(4)A3'and 5'(A/T)(3)(-4)A3', respectively]. We used these drugs to examine the determinants for region-specific damage of human genomic DNA. The distribution of bizelesin binding motifs in several regions analyzed "in silico" correlated well with the experimentally determined lesions in these regions assessed by quantitative polymerase chain reaction (QPCR… CONTINUE READING

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