Region-dependent changes in endocannabinoid transmission in the brain of morphine-dependent rats.

@article{Gonzlez2003RegiondependentCI,
  title={Region-dependent changes in endocannabinoid transmission in the brain of morphine-dependent rats.},
  author={Sara Gonz{\'a}lez and Patricia C. Schmid and Javier Fern{\'a}ndez-Ruiz and Randy J. Krebsbach and Harald H. O. Schmid and Jos{\'e} Antonio Vera Ramos},
  journal={Addiction biology},
  year={2003},
  volume={8 2},
  pages={159-66}
}
It has been suggested recently that the endocannabinoid system might be a component of the brain reward circuitry and thus play a role not only in cannabinoid tolerance/dependence, but also in dependence/withdrawal to other drugs of abuse. Here we have examined the changes in endocannabinoid ligands and their receptors in different brain regions, with particular attention to those areas related to reinforcement processes, during dependence on the powerful addictive drug, morphine. Thus, we… CONTINUE READING

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