Region- and peptide-specific regulation of the neurotrophins by estrogen.

  title={Region- and peptide-specific regulation of the neurotrophins by estrogen.},
  author={Melinda K Jezierski and Farida Sohrabji},
  journal={Brain research. Molecular brain research},
  volume={85 1-2},
We have previously shown that estrogen increases the expression of brain-derived neurotrophic factor (BDNF) mRNA in the olfactory bulb and cingulate cortex. Here we report that estrogen regulation of BDNF protein and the structurally related peptides nerve growth factor (NGF) and neurotrophin (NT)-4 is region- and peptide-specific. The olfactory bulb and cingulate cortex are both estrogen-sensitive targets and each receives a separate projection from neurons in the horizontal limb of the… CONTINUE READING
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