Regioisomeric differentiation of mono-methoxy ring-substituted amphetamine and methamphetamine by GC-MS

Abstract

The 2-, 3-, and 4-methoxyamphetamines and methoxymethamphetamines were prepared and analyzed by GC-MS. Regioisomerism at the aromatic ring in these compounds possess similar analytical properties. They show similar gas chromatographic retention properties on a column with phenylmethylsilicone (HP-5) stationary phase. The mass spectra for the underivatized amines are similar and fail to provide sufficient information to differentiate the ring regioisomers. Preparation of the pentafluoropropionylamide derivatives provides adequate GC resolution and distinct mass spectra that can be used to differentiate these regioisomeric amines.

Cite this paper

@inproceedings{Liu2003RegioisomericDO, title={Regioisomeric differentiation of mono-methoxy ring-substituted amphetamine and methamphetamine by GC-MS}, author={Ju-Tsung Liu}, year={2003} }