Regio- and stereospecific rhodium-catalyzed allylic alkylation with an acyl anion equivalent: an approach to acyclic α-ternary β,γ-unsaturated aryl ketones† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05705e Click here for additional data file.

@inproceedings{Turnbull2017RegioAS,
  title={Regio- and stereospecific rhodium-catalyzed allylic alkylation with an acyl anion equivalent: an approach to acyclic α-ternary β,γ-unsaturated aryl ketones†
†Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05705e
Click here for additional data file.

},
  author={Ben W H Turnbull and Jungha Chae and Samuel S. Oliver and P Andrew Evans},
  booktitle={Chemical science},
  year={2017}
}
The regio- and stereospecific rhodium-catalyzed allylic alkylation of secondary allylic carbonates with cyanohydrin pronucleophiles facilitates the direct construction of acyclic α-ternary β,γ-unsaturated aryl ketones. Interestingly, this study illustrates the impact of deaggregating agents on regiocontrol and the electronic nature of the aryl component to suppress olefin isomerization. In addition, we demonstrate that the dimethylamino substituent, which modulates the pKa of the α-ternary… CONTINUE READING