Regio- and stereoselective access to novel ring-condensed steroidal isoxazolines.

Abstract

Novel 5α-androstanes containing an isoxazoline moiety condensed to ring A or D were efficiently synthetized by 1,3-dipolar cycloadditions of aryl nitrile oxides to steroidal α,β-unsaturated ketones. During the ring closures, regioisomers in which the O terminus of the nitrile oxide dipoles is attached to the β-carbon of the dipolarophile were formed in a… (More)
DOI: 10.1016/j.steroids.2014.05.019

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Cite this paper

@article{Mtyn2014RegioAS, title={Regio- and stereoselective access to novel ring-condensed steroidal isoxazolines.}, author={Gergő M{\'o}ty{\'a}n and Zal{\'a}n K{\'a}d{\'a}r and D{\'o}ra Kov{\'a}cs and J{\'a}nos W{\"{o}lfling and {\'E}va Frank}, journal={Steroids}, year={2014}, volume={87}, pages={76-85} }