Regio- and stereoselective synthesis of (E)-alkene trans-Xaa-Pro dipeptide mimetics utilizing organocopper-mediated anti-S(N)2' reactions.

Abstract

Proline dipeptides (Xaa-Pro) exist as an equilibrium mixture of cis- and trans-rotamers, which depends on the energy barriers for imide isomerization. This conformation mixture contributes to both structure and function of proline-containing peptides and proteins. Structural motifs resembling these cis- or trans-conformers have served as useful tools for… (More)

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Cite this paper

@article{Otaka2002RegioAS, title={Regio- and stereoselective synthesis of (E)-alkene trans-Xaa-Pro dipeptide mimetics utilizing organocopper-mediated anti-S(N)2' reactions.}, author={Akira Otaka and Fumihiko Katagiri and Takayoshi Kinoshita and Yoshihiko Odagaki and Shinya Oishi and Hirokazu Tamamura and Nobuyuki Hamanaka and N. Fujii}, journal={The Journal of organic chemistry}, year={2002}, volume={67 17}, pages={6152-61} }