Regimen-related toxicity in patients undergoing bone marrow transplantation.

  title={Regimen-related toxicity in patients undergoing bone marrow transplantation.},
  author={Scott I. Bearman and Frederick R Appelbaum and C. Dean Buckner and Finn Bo Petersen and Lloyd D Fisher and Reginald A. Clift and E. Donnall Thomas},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={6 10},
Bone marrow transplantation is associated with significant morbidity and mortality, some of which is due to high-dose chemoradiotherapy. In order to quantitate toxicity that was felt to be due to the preparative regimen (termed regimen-related toxicity [RRT]), a system was developed in which toxicities were graded from 0 (none) to 4 (fatal). One hundred ninety-five patients who underwent marrow transplantation for leukemia were studied retrospectively to determine whether toxicities that were… CONTINUE READING


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