Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila

Abstract

The lipid-modified morphogens Wnt and Hedgehog diffuse poorly in isolation yet can spread over long distances in vivo, predicting existence of two distinct forms of these morphogens. The first is poorly mobile and activates short-range target genes. The second is specifically packed for efficient spreading to induce long-range targets. Subcellular… (More)
DOI: 10.1038/sj.emboj.7601981

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Cite this paper

@article{Katanaev2008Reggie1flotillin2PS, title={Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila}, author={Vladimir L Katanaev and Gonzalo P. Solis and George Hausmann and Silke Buestorf and Natalya Katanayeva and Yvonne Schrock and Claudia A O Stuermer and Konrad Basler}, journal={The EMBO Journal}, year={2008}, volume={27}, pages={509 - 521} }