Regenerative therapy and cancer: in vitro and in vivo studies of the interaction between adipose-derived stem cells and breast cancer cells from clinical isolates.

@article{Zimmerlin2011RegenerativeTA,
  title={Regenerative therapy and cancer: in vitro and in vivo studies of the interaction between adipose-derived stem cells and breast cancer cells from clinical isolates.},
  author={Ludovic Zimmerlin and Albert D. Donnenberg and J Peter Rubin and Per Basse and Rodney J. Landreneau and Vera S Donnenberg},
  journal={Tissue engineering. Part A},
  year={2011},
  volume={17 1-2},
  pages={93-106}
}
Adipose-derived stem cells (ASCs) have been proposed to stabilize autologous fat grafts for regenerative therapy, but their safety is unknown in the setting of reconstructive surgery after mastectomy. Both bone marrow mesenchymal stem cells (MSCs) and ASC have been shown to enhance tumorigenesis of established breast cancer cell lines, but primary patient material has not been tested. Here, we ask whether ASC promote the in vitro growth and in vivo tumorigenesis of metastatic breast cancer… CONTINUE READING
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