Regenerative medicine: Inhibiting Hippo repairs tissue

Abstract

The Hippo signalling pathway has a pivotal role in regulating stem cell renewal, tissue regeneration and organ size control. Fan et al. now describe the use of an enzyme-linked immunosorbent assay (ELISA)-based high-throughput screen of a kinase-directed compound library, to identify the benzenesulfonamide-based small molecule XMU-MP-1 as a reversible… (More)
DOI: 10.1038/nrd.2016.194

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