Regenerative Versus Reparative Healing in Tendon: A Study of Biomechanical and Histological Properties in Fetal Sheep

@article{Beredjiklian2003RegenerativeVR,
  title={Regenerative Versus Reparative Healing in Tendon: A Study of Biomechanical and Histological Properties in Fetal Sheep},
  author={Pedro K. Beredjiklian and Michele Favata and Jeffrey Stuart Cartmell and Colleen L. Flanagan and Timothy M. Crombleholme and Louis J Soslowsky},
  journal={Annals of Biomedical Engineering},
  year={2003},
  volume={31},
  pages={1143-1152}
}
AbstractPrevious studies have shown fetal tissues heal in a regenerative fashion without scar formation. The objective of this study is to compare the healing properties of adult and fetal tendons. Time-mated pregnant ewes at 80–85 days of gestation were utilized. A partial, midsubstance tenotomy was performed in the lateral extensor fetal tendons, and analogous tenotomies were created in the maternal limbs. One week after injury, the fetal and adult animals were sacrificed, and tendons were… CONTINUE READING
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