Regenerative Response in Ischemic Brain Restricted by p21cip1/waf1

  title={Regenerative Response in Ischemic Brain Restricted by p21cip1/waf1},
  author={Jian-hua Qiu and Yasushi Takagi and Jun Harada and Neil P. Rodrigues and Michael A. Moskowitz and David T Scadden and Tao Cheng},
  journal={The Journal of Experimental Medicine},
  pages={937 - 945}
Neural precursor cells from adults have exceptional proliferative and differentiative capability in vitro yet respond minimally to in vivo brain injury due to constraining mechanisms that are poorly defined. We assessed whether cell cycle inhibitors that restrict stem cell populations in other tissues may participate in limiting neural stem cell reactivity in vivo. The cyclin-dependent kinase inhibitor, p21cip1/waf1 (p21), maintains hematopoietic stem cell quiescence, and we evaluated its role… CONTINUE READING
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