Regeneration of the canine urinary bladder mucosa after complete surgical denudation.

@article{Wishnow1989RegenerationOT,
  title={Regeneration of the canine urinary bladder mucosa after complete surgical denudation.},
  author={K I Wishnow and Douglas R E Johnson and David J. Grignon and Douglas M. Cromeens and Alberto G. Ayala},
  journal={The Journal of urology},
  year={1989},
  volume={141 6},
  pages={1476-9}
}
To study the site of origin of epithelial regeneration in the urinary bladder after surgical denudation, we completely obliterated the bladder mucosa in 17 dogs, using the neodymium: YAG laser. Bladder-mapping studies showed that the regenerating cells arose from the epithelium of the terminal ureters and urethra. Experimental construction of isolated bladder pouches confirmed these findings and demonstrated that urine flow was not essential for reepithelialization. These results are relevant… CONTINUE READING