Regeneration of hyaline cartilage by cell-mediated gene therapy using transforming growth factor beta 1-producing fibroblasts.

@article{Lee2001RegenerationOH,
  title={Regeneration of hyaline cartilage by cell-mediated gene therapy using transforming growth factor beta 1-producing fibroblasts.},
  author={K. Lee and S. Song and T. Hwang and Y. Yi and I. Oh and J. Lee and K. Choi and M. S. Choi and S. Kim},
  journal={Human gene therapy},
  year={2001},
  volume={12 14},
  pages={
          1805-13
        }
}
Transforming growth factor beta (TGF-beta) has been considered as a candidate for gene therapy of orthopedic diseases. The possible application of cell-mediated TGF-beta gene therapy as a new treatment regimen for degenerative arthritis was investigated. In this study, fibroblasts expressing active TGF-beta 1 were injected into the knee joints of rabbits with artificially made cartilage defects to evaluate the feasibility of this therapy for orthopedic diseases. Two to 3 weeks after the… Expand
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References

SHOWING 1-10 OF 29 REFERENCES
Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur
Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint.
Repair of Articular Cartilage Defects One Year After Treatment with Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2)*
The Effect of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) on the Healing of Full-Thickness Defects of Articular Cartilage*
Effect of transforming growth factor-beta on proteoglycan synthesis by chondrocytes in relation to differentiation stage and the presence of pericellular matrix.
Use of recombinant human osteogenic protein-1 for the repair of subchondral defects in articular cartilage in goats.
Cell origin and differentiation in the repair of full-thickness defects of articular cartilage.
Recombinant Transforming Growth Factor‐β1 Induces Endochondral Bone in the Baboon and Synergizes with Recombinant Osteogenic Protein‐1 (Bone Morphogenetic Protein‐7) to Initiate Rapid Bone Formation
...
1
2
3
...