Regeneration of corneal epithelium utilizing a collagen vitrigel membrane in rabbit models for corneal stromal wound and limbal stem cell deficiency.

@article{Chae2015RegenerationOC,
  title={Regeneration of corneal epithelium utilizing a collagen vitrigel membrane in rabbit models for corneal stromal wound and limbal stem cell deficiency.},
  author={Jemin Jeremy Chae and Winnette McIntosh Ambrose and Freddy A Espinoza and Daniel G Mulreany and Shengyong Ng and Toshiaki Takezawa and Morgana M. Trexler and Oliver Schein and Roy S. H. Chuck and Jennifer H Elisseeff},
  journal={Acta ophthalmologica},
  year={2015},
  volume={93 1},
  pages={e57-66}
}
PURPOSE This study was performed to evaluate the potential of a collagen-based membrane, collagen vitrigel (CV), for reconstructing corneal epithelium in the stromal wound and limbal stem cell deficiency (LSCD) models. METHODS Three groups of rabbits were used in the stromal wound model: CV affixed using fibrin glue (CV + FG group, n = 9), fibrin glue only (FG group, n = 3) and an untreated control group (n = 3). In the LSCD model, one group received CV containing human limbal epithelial… CONTINUE READING