Regeneration in zebrafish lateral line neuromasts: expression of the neural progenitor cell marker sox2 and proliferation-dependent and-independent mechanisms of hair cell renewal.

@article{Hernndez2007RegenerationIZ,
  title={Regeneration in zebrafish lateral line neuromasts: expression of the neural progenitor cell marker sox2 and proliferation-dependent and-independent mechanisms of hair cell renewal.},
  author={Pedro P Hern{\'a}ndez and Francisco A Olivari and Andr{\'e}s F Sarrazin and Pablo C. Sandoval and Miguel L. Allende},
  journal={Developmental neurobiology},
  year={2007},
  volume={67 5},
  pages={637-54}
}
Mechanosensory hair cells are essential for audition in vertebrates, and in many species, have the capacity for regeneration when damaged. Regeneration is robust in the fish lateral line system as new hair cells can reappear after damage induced by waterborne aminoglycoside antibiotics, platinum-based drugs, and heavy metals. Here, we characterize the loss and reappearance of lateral line hair cells induced in zebrafish larvae treated with copper sulfate using diverse molecular markers… CONTINUE READING