Regeneration in axolotls: a model to aim for!

@article{Roy2008RegenerationIA,
  title={Regeneration in axolotls: a model to aim for!},
  author={St{\'e}phane Roy and Samuel Gatien},
  journal={Experimental Gerontology},
  year={2008},
  volume={43},
  pages={968-973}
}
Urodele amphibians such as the axolotl are the champions of tissue regeneration amongst vertebrates. These animals have mastered the ability to repair and replace most of their tissues following damage or amputation even well into adulthood. In fact it seems that the ability of these organisms to regenerate perfectly is not affected by their age. In addition to being able to regenerate, these animals display a remarkable resistance to cancer. They therefore represent a unique model organism to… Expand

Paper Mentions

A histological study of normal and pathological limb regeneration in the Mexican axolotl Ambystoma mexicanum.
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The results demonstrate that regenerated forelimbs show a diversity of limb and digit abnormalities as a result of imperfect regeneration and indicate that abnormalities occur frequently after regeneration in larval axolotls contradicting the notion of regeneration generally resulting in perfect limbs. Expand
Understanding regeneration through proteomics
TLDR
The present review focuses on the significant knowledge brought up by proteomics in diverse aspects of regeneration research on different animal models, tissues, and organs. Expand
Highly efficient targeted mutagenesis in axolotl using Cas9 RNA-guided nuclease
TLDR
It is reported that the CRISPR-Cas9 RNA-guided nuclease system can efficiently create mutations at targeted sites within the axolotl genome and will undoubtedly provide invaluable insight into the mechanisms of salamanders' unique regenerative ability. Expand
Identification of Conserved and Novel MicroRNAs during Tail Regeneration in the Mexican Axolotl
TLDR
These findings support the hypothesis that microRNAs play key roles in managing the precise spatial and temporal patterns of gene expression that ensures the correct regeneration of missing tissues in the axolotl. Expand
Endocrine regulation of regeneration: Linking global signals to local processes.
TLDR
The cumulative knowledge known about endocrine regulation of regeneration and important future research directions of interest to both ecological and biomedical research are discussed. Expand
The thymus and tail regenerative capacity in Xenopus laevis tadpoles.
TLDR
In older larvae, whose capacity to form a new complete and correctly patterned tail was reduced, thymic morphological changes were more severe and may persist throughout the regeneration process with a significant reduction in organ size, which may be related to the events occurring during regeneration. Expand
Whole-Body Regeneration in the Colonial Tunicate Botrylloides leachii.
TLDR
A synthesis of the current knowledge on WBR in B. leachii is provided to support research in this chordate species and in related species of tunicates. Expand
Transcriptional landscapes of Axolotl (Ambystoma mexicanum).
TLDR
One of the most diverse transcriptomic data sets for Axolotl is presented by profiling coding and non-coding RNAs from diverse tissues by reconstructing a population of 115,906 putative protein coding mRNAs as full ORFs (including isoforms). Expand
Aging delays epimorphic regeneration in mice.
TLDR
It is shown for the first time that aging derails the spatiotemporal regulation of epimorphic regeneration in mammals, first, by exacerbating tissue histolysis and delaying wound closure, and second, by impairing blastema differentiation and skeletal regrowth. Expand
Phylogeny, regeneration, ageing and cancer: role of microenvironment and possibility of its therapeutic manipulation.
TLDR
The probable role of micro environment in all the discussed phenomena such as healing/regeneration, inflammation, and cancer is discussed and targeting of microenvironment is consequently predicted as a possible therapeutic target where controlled manipulation may represent a new approach to the treatment of cancer patients. Expand
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TLDR
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TLDR
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TLDR
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