Regeneration and the immune system I. In vitro and in vivo activation of lymphocytes by liver regeneration and the role of Kupffer cells in stimulation

@article{Miyahara1983RegenerationAT,
  title={Regeneration and the immune system I. In vitro and in vivo activation of lymphocytes by liver regeneration and the role of Kupffer cells in stimulation},
  author={Satoko Miyahara and Kozo Yokomuro and H K Takahashi and Yoshitami Kimura},
  journal={European Journal of Immunology},
  year={1983},
  volume={13}
}
When syngeneic lymphocytes and mitomycin C‐treated regenerating liver cells, prepared from partially hepatectomized mice, are cultured together, the in vitro DNA synthesis is activated (sMLHLR: syngeneic mixed hepatectomized‐liver cell‐lymphocyte culture). The Ia+ Kupffer cells play an important role as stimulators in the response, since the stimulating activity of regenerating liver cells is lost either by the pretreatment with anti‐Ia monoclonal antibody plus complement or by the removing… Expand
Regeneration and the immune system II. Suppressor activities of lymphocytes activated in vivo by liver regeneration and their genetic control
TLDR
The lymph node cells activated in vivo by liver regeneration following partial hepatectomy of mice respond to regenerating liver cells in vitro with typical secondary immune response characteristics and are effective not only on sMLHLR but also on syngeneic mixed lymphocyte culture (sMLR), of which responder cells share the I‐A (I‐B) subregions of the major histocompatibility complex (MHC). Expand
The augmentation of lymphokine-activated killer cells induced by partial hepatectomy in mice
TLDR
Analysis by cell depletion techniques using monoclonal antibodies and complement, as well as discontinuous gradient sedimentation, indicated that the LAK cells activated by HEP were Thy-1+, LyT-2+, asialo GM1+ and Lyt-1−, lymphocytes with a low density. Expand
Changes of liver-resident NK cells during liver regeneration in rats.
TLDR
The data suggest that liver-resident NK cells may be involved in regulation of the extent of liver regeneration, and in vivo depletion of NK cells by injection of rats with anti-NKR-P1 mAb resulted in a significant augmentation of Liver regeneration subsequent to partial hepatectomy. Expand
Immunological tolerance induced by liver grafting in the rat: splenic macrophages and T cells mediate distinct phases of immunosuppressive activity
TLDR
It is concluded that liver grafting in this combination generates early and late phases of suppression among spleen cells, that the early phase is produced by macrophages and mediated by prostaglandins and that the late phase is dependent on allospecific suppressor T cells. Expand
Suppression of liver regeneration resulting from intravenous injection of splenic glass adherent cells activated by poly I:C.
TLDR
It is demonstrated that the activated immune system may have some regulatory effects on liver regeneration as well as the results suggest that the suppressive activity of IC-SACs was not solely caused by the poly I:C carried into the mice with IC- sACs but by the activated IC- SACs themselves. Expand
Role of shear stress and immune responses in liver regeneration after a partial hepatectomy
TLDR
It is proposed that the acute elevation of shear stress after PHx influences the adhesion between SEC and intrahepatic leukocytes, and is expected to positively contribute to the future research on liver regeneration afterPHx. Expand
Cyclosporine enhances liver regeneration: the role of hepatocyte MHC expression and PGE2--a study relevant to graft immunogenicity.
TLDR
It is proposed that the enhancing effect of CsA on hepatocyte proliferation is by means of an indirect mechanism that can be attributed to a) reduced immunogenicity of the regenerating liver as a result of inhibition of class I and II MHC hepatocyte expression and b) increased PGE2 synthesis in the liver mediated by its action on EP1 receptor. Expand
Rat peripheral mononuclear cell thymidine kinase activity increases during liver regenerative processes after partial hepatectomy
  • M. Morimoto, K. Numata, KATSUAKI TANAKA
  • Biology, Medicine
  • Journal of gastroenterology and hepatology
  • 1995
TLDR
The results indicate that in the early stage of liver regeneration PMNC‐TK may provide a marker of liver regenerative processes. Expand
Effects of partial hepatectomy on the immune responses in mice.
TLDR
It is suggested that partial hepatectomy creating liver deficiency followed by regeneration may be a useful experimental model to study the immune status of various forms of hepatic damage. Expand
Molecular mechanisms of augmenter of liver regeneration as immunoregulator: its effect on interferon-gamma expression in rat liver.
  • L. Polimeno, M. Margiotta, +6 authors A. Francavilla
  • Biology, Medicine
  • Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2000
TLDR
The pivotal role of Augmenter of Liver Regeneration as Growth Factor and as immunoregulator is demonstrated by controlling, through Interferon-gamma levels, the mitochondrial transcription factor A expression and the lytic activity of liver-resident Natural Killer cells. Expand
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Regeneration and the immune system II. Suppressor activities of lymphocytes activated in vivo by liver regeneration and their genetic control
TLDR
The lymph node cells activated in vivo by liver regeneration following partial hepatectomy of mice respond to regenerating liver cells in vitro with typical secondary immune response characteristics and are effective not only on sMLHLR but also on syngeneic mixed lymphocyte culture (sMLR), of which responder cells share the I‐A (I‐B) subregions of the major histocompatibility complex (MHC). Expand
Liver and immune responses. V: Regenerating liver cells activate syngeneic lymphocytes.
TLDR
Lymphocyte stimulating differentiation antigens may be involved in the process of hepatic regeneration as well as in the study of regenerating liver cells to stimulate in vitro DNA synthetic response of syngeneic lymphocytes. Expand
The murine Kupffer cell. I. Characterization of the cell serving accessory function in antigen-specific T cell proliferation.
TLDR
It is concluded that isolated murine K upffer cells bear the Ia phenotype of accessory cells that function in antigen presentation and that Kupffer cells can participate in the induction of antigen-specific immune responses. Expand
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T helper cells do not exhibit invariant expression of the Lyt‐1,2 alloantigens, and are therefore not resistant to treatment with anti‐Lyt‐1 and complement. Expand
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TLDR
Liver regeneration appears to be partly mediated by short-lived RNA molecules, the synthesis of which commences rapidly after partial hepatectomy and ceases at various times during the regenerative process. Expand
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  • Biology, Medicine
  • International review of cytology
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TLDR
The chapter reviews experimental studies on the homeostatic control of hepatic growth, as exemplified primarily by regeneration in response to partial hepatectomy, with particular attention to the first cycle of cellular growth and division. Expand
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TLDR
This analysis indicates that the molecular basis of "self-recognition" is the identity of some or all of the polypeptide chains of lymphoid MCPs and their corresponding target tissue TCFs, which account for the specificity of interactions in the central feedback control of symmetrical mitosis. Expand
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