Regeneration and the immune system I. In vitro and in vivo activation of lymphocytes by liver regeneration and the role of Kupffer cells in stimulation

@article{Miyahara1983RegenerationAT,
  title={Regeneration and the immune system I. In vitro and in vivo activation of lymphocytes by liver regeneration and the role of Kupffer cells in stimulation},
  author={Satoko Miyahara and Kozo Yokomuro and H K Takahashi and Yoshitami Kimura},
  journal={European Journal of Immunology},
  year={1983},
  volume={13}
}
When syngeneic lymphocytes and mitomycin C‐treated regenerating liver cells, prepared from partially hepatectomized mice, are cultured together, the in vitro DNA synthesis is activated (sMLHLR: syngeneic mixed hepatectomized‐liver cell‐lymphocyte culture). The Ia+ Kupffer cells play an important role as stimulators in the response, since the stimulating activity of regenerating liver cells is lost either by the pretreatment with anti‐Ia monoclonal antibody plus complement or by the removing… 

Regeneration and the immune system II. Suppressor activities of lymphocytes activated in vivo by liver regeneration and their genetic control

TLDR
The lymph node cells activated in vivo by liver regeneration following partial hepatectomy of mice respond to regenerating liver cells in vitro with typical secondary immune response characteristics and are effective not only on sMLHLR but also on syngeneic mixed lymphocyte culture (sMLR), of which responder cells share the I‐A (I‐B) subregions of the major histocompatibility complex (MHC).

The augmentation of lymphokine-activated killer cells induced by partial hepatectomy in mice

TLDR
Analysis by cell depletion techniques using monoclonal antibodies and complement, as well as discontinuous gradient sedimentation, indicated that the LAK cells activated by HEP were Thy-1+, LyT-2+, asialo GM1+ and Lyt-1−, lymphocytes with a low density.

Changes of liver-resident NK cells during liver regeneration in rats.

TLDR
The data suggest that liver-resident NK cells may be involved in regulation of the extent of liver regeneration, and in vivo depletion of NK cells by injection of rats with anti-NKR-P1 mAb resulted in a significant augmentation of Liver regeneration subsequent to partial hepatectomy.

Immunological tolerance induced by liver grafting in the rat: splenic macrophages and T cells mediate distinct phases of immunosuppressive activity

TLDR
It is concluded that liver grafting in this combination generates early and late phases of suppression among spleen cells, that the early phase is produced by macrophages and mediated by prostaglandins and that the late phase is dependent on allospecific suppressor T cells.

Role of shear stress and immune responses in liver regeneration after a partial hepatectomy

TLDR
It is proposed that the acute elevation of shear stress after PHx influences the adhesion between SEC and intrahepatic leukocytes, and is expected to positively contribute to the future research on liver regeneration afterPHx.

Cyclosporine enhances liver regeneration: the role of hepatocyte MHC expression and PGE2--a study relevant to graft immunogenicity.

TLDR
It is proposed that the enhancing effect of CsA on hepatocyte proliferation is by means of an indirect mechanism that can be attributed to a) reduced immunogenicity of the regenerating liver as a result of inhibition of class I and II MHC hepatocyte expression and b) increased PGE2 synthesis in the liver mediated by its action on EP1 receptor.

Rat peripheral mononuclear cell thymidine kinase activity increases during liver regenerative processes after partial hepatectomy

TLDR
The results indicate that in the early stage of liver regeneration PMNC‐TK may provide a marker of liver regenerative processes.

Effects of partial hepatectomy on the immune responses in mice.

Molecular mechanisms of augmenter of liver regeneration as immunoregulator: its effect on interferon-gamma expression in rat liver.

  • L. PolimenoM. Margiotta A. Francavilla
  • Biology, Medicine
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2000

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Regeneration and the immune system II. Suppressor activities of lymphocytes activated in vivo by liver regeneration and their genetic control

TLDR
The lymph node cells activated in vivo by liver regeneration following partial hepatectomy of mice respond to regenerating liver cells in vitro with typical secondary immune response characteristics and are effective not only on sMLHLR but also on syngeneic mixed lymphocyte culture (sMLR), of which responder cells share the I‐A (I‐B) subregions of the major histocompatibility complex (MHC).

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TLDR
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TLDR
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TLDR
The results indicate that the mechanisms of cell-cell recognition necessary in secondary MLR against K or D region gene products are different from those in primary MLR to the same products.