Regeneration and orthotopic transplantation of a bioartificial lung

@article{Ott2010RegenerationAO,
  title={Regeneration and orthotopic transplantation of a bioartificial lung},
  author={Harald C. Ott and Ben jamin Clippinger and C. Labandeira Conrad and Christian Schuetz and Irina Pomerantseva and Laertis Ikonomou and Darrell N. Kotton and Joseph Phillip Vacanti},
  journal={Nature Medicine},
  year={2010},
  volume={16},
  pages={927-933}
}
About 2,000 patients now await a donor lung in the United States. Worldwide, 50 million individuals are living with end-stage lung disease. Creation of a bioartificial lung requires engineering of viable lung architecture enabling ventilation, perfusion and gas exchange. We decellularized lungs by detergent perfusion and yielded scaffolds with acellular vasculature, airways and alveoli. To regenerate gas exchange tissue, we seeded scaffolds with epithelial and endothelial cells. To establish… CONTINUE READING
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