Regeneration and Repair

  title={Regeneration and Repair},
  author={Rachel S. Friedman and Diane S. Krause},
  journal={Annals of the New York Academy of Sciences},
When it comes to the capacity to regenerate damaged parts of the body, humans are by no means the most advanced among animal species. At the level of single cell populations, humans do exhibit some degree of regenerative potential‐‐for example, hepatocytes have the ability to restore up to 75% of a surgically removed or damaged liver. However, as every schoolchild knows, salamanders and starfish can regrow entire amputated appendages, a remarkable feat well beyond the scope of human capacity… 
The emerging role of microvesicles in cellular therapies for organ/tissue regeneration.
  • M. Ratajczak
  • Biology, Medicine
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2011
E elegant evidence is provided that some crucial protective and pro-regenerative mechanisms are mediated by cell-derived microvesicles (MVs), which emerged very early during evolution and served as a template for the further development of intercellular interaction mechanisms involving soluble bioactive mediators and fine-tuned ligand–receptor interactions.
Paracrine Effects of Fetal Stem Cells
Constant media harvested from cultured in vitro ESCs, enriched in soluble factors and ExMVs, could be employed in regenerative medicine as therapeutics to treat damaged organs.
Microvesicles and Their Emerging Role in Cellular Therapies for Organ and Tissue Regeneration
The potential use of MVs, instead of whole cells, has become an exciting new concept in regenerative medicine because of its potential to improve overall cell function.
mesenchymal stem cells novel therapeutic option besides their stem cell properties utilizing the niche effect
MSC’s may be used for direct clinical effects but its manipulation of host response in different occasions via cell-cell actions including through production of bioactive secreted factors which include smallproteins, chemokines, cytokines & other cellular regulators.
Developmental and Regenerative Biology of Cardiomyocytes.
A bird's-eye view on the current knowledge and potential pitfalls in the field of developmental biology-guided regenerative medicine strategies for the treatment of heart diseases is provided.
A Review on Modifications of Amniotic Membrane for Biomedical Applications
This article discusses the cases in which AM has undergone additional modifications besides the required processes for sterilization and preservation, and categorized these modifications and discussed their applications and results.
Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes?
A possible stem cell mechanism involved in the development of metabolic syndrome is proposed and could open the possibility for a new strategy of treatment in metabolic syndrome, lipodystrophic syndromes, progeria, and even aging: stem cell therapies.
Interstitial lung disease: physiopathology in the context of lung growth.
Bone Anatomy and the Biologic Healing Process of a Fracture
Fracture healing is completed by the remodeling phase characterized by the balance between osteoblast and osteoclast functions under both systemic and local control pathways.
Two-Chambered Chitosan Nerve Guides With Increased Bendability Support Recovery of Skilled Forelimb Reaching Similar to Autologous Nerve Grafts in the Rat 10 mm Median Nerve Injury and Repair Model
Histological and nerve morphometrical evaluations, in accordance to the functional results, demonstrated best outcome in the ANG group and highest myelin thicknesses in the corrCNG[F] group compared to the CNG and CNG [F] groups.


Skeletal muscle regeneration in very old rats.
It is shown that under appropriate conditions, very old muscles can regenerate to equal or exceed the contralateral control values, which in old rats are much less than those in muscles of young rats.
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Heterochronic parabiosis increased aged hepatocyte proliferation and restored the cEBP-α complex to levels seen in young animals, suggesting that the age-related decline of progenitor cell activity can be modulated by systemic factors that change with age.
Stem cells, ageing and the quest for immortality
Unravelling distinct contributions to the aged phenotype will be critical to the success of any therapeutic application of stem cells in the emerging field of regenerative medicine with respect to tissue injury, degenerative diseases or normal functional declines that accompany ageing.
Bone marrow to liver: the blood of Prometheus.
Plasticity of marrow-derived stem cells
A brief overview of recent findings in somatic stem cell plasticity is summarized.
Mobilized bone marrow cells repair the infarcted heart, improving function and survival
Attempts to repair myocardial infarcts by transplanting cardiomyocytes or skeletal myoblasts have failed to reconstitute healthy myocardium and coronary vessels integrated structurally and
Myogenic satellite cells: physiology to molecular biology.
This review will highlight the origin and unique markers of the satellite cell population, the regulation by growth factors, and the response to physiological and pathological stimuli, and identify future research goals for the study of satellite cell biology.
Hepatic regeneration from hematopoietic stem cells
Notch-Mediated Restoration of Regenerative Potential to Aged Muscle
Analysis of injured muscle revealed that, with age, resident precursor cells had a markedly impaired propensity to proliferate and to produce myoblasts necessary for muscle regeneration, and Notch signaling is a key determinant of muscle regenerative potential that declines with age.
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
It is reported that intravenous injection of adult bone marrow cells in the FAH−/− mouse, an animal model of tyrosinemia type I, rescued the mouse and restored the biochemical function of its liver.