RegA Plays a Key Role in Oxygen-Dependent Establishment of Persistence and in Isocitrate Lyase Activity, a Critical Determinant of In vivo Brucella suis Pathogenicity

@inproceedings{Abdou2017RegAPA,
  title={RegA Plays a Key Role in Oxygen-Dependent Establishment of Persistence and in Isocitrate Lyase Activity, a Critical Determinant of In vivo Brucella suis Pathogenicity},
  author={Elias Abdou and Mar{\'i}a Pilar Jim{\'e}nez de Bag{\"u}{\'e}s and Ignacio Mart{\'i}nez-Abad{\'i}a and Safia Ouahrani-Bettache and V{\'e}ronique Pantesco and Alessandra Occhialini and Sascha Al Dahouk and Stephan K{\"o}hler and V{\'e}ronique Jubier-Maurin},
  booktitle={Front. Cell. Infect. Microbiol.},
  year={2017}
}
For aerobic human pathogens, adaptation to hypoxia is a critical factor for the establishment of persistent infections, as oxygen availability is low inside the host. The two-component system RegB/A of Brucella suis plays a central role in the control of respiratory systems adapted to oxygen deficiency, and in persistence in vivo. Using an original "in vitro model of persistence" consisting in gradual oxygen depletion, we compared transcriptomes and proteomes of wild-type and ΔregA strains to… CONTINUE READING