Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in mice.

@article{Lieu2006Reg2II,
  title={Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in mice.},
  author={Hanh-Tu Lieu and M Simon and Thao Nguyen-Khoa and Messeret Kebede and Alexandre Cortes and Luis Tebar and Andrew J. H. Smith and Rosemary Bayne and Stephen P. Hunt and Christian Br{\'e}chot and Laurence Christa},
  journal={Hepatology},
  year={2006},
  volume={44 6},
  pages={1452-64}
}
Reg2/RegIIIbeta is the murine homologue of the human secreted HIP/PAP C-type lectin. HIP/PAP transgenic mice were protected against acetaminophen-induced acute liver failure and were stimulated to regenerate post-hepatectomy. To assess the role of Reg2, we used Reg2-/- mice in a model of fulminant hepatitis induced by Fas and in the post-hepatectomy regeneration. Within 4 hours of J0-2 treatment (0.5 microg/g), only 50% of the Reg2-/- mice were alive but with an increased sensitivity to Fas… CONTINUE READING

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