Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation.

@article{Zhong2007RegIIIA,
  title={Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation.},
  author={Bihui Zhong and Pavel Strnad and D M Toivola and G Z Tao and Xuhuai Ji and Harry B Greenberg and M. Bishr Omary},
  journal={Molecular biology of the cell},
  year={2007},
  volume={18 12},
  pages={
          4969-78
        }
}
The major keratins in the pancreas and liver are keratins 8 and 18 (K8/K18), but their function seemingly differs in that liver K8/K18 are essential cytoprotective proteins, whereas pancreatic K8/K18 are dispensable. This functional dichotomy raises the hypothesis that K8-null pancreata may undergo compensatory cytoprotective gene expression. We tested this hypothesis by comparing the gene expression profile in pancreata of wild-type and K8-null mice. Most prominent among the up-regulated genes… CONTINUE READING