Refractory to Rituximab-Based B-Cell Depletion Therapy on Chronic Skin Manifestations of Systemic Lupus Erythematosus : Case Report

In this case report, we present a patient with systemic lupus erythematosus who has both refractory discoid lupus erythematosus lesions and refractory cytopenia under antimalarial, glucocorticoid and untarget immunosuppressant drugs. Rituximab, a monoclonal antibody directed against the CD20 antigen on the surface of B-lymphocytes has been used as an… (More)