Refractory schizophrenia and atypical antipsychotics

@article{Taylor2000RefractorySA,
  title={Refractory schizophrenia and atypical antipsychotics},
  author={David Taylor and David Taylor and Denise Duncan-McConnell},
  journal={Journal of Psychopharmacology},
  year={2000},
  volume={14},
  pages={409 - 418}
}
Treatment resistant or refractory schizophrenia is a difficult to define condition of largely unknown prevalence. For 10 years, clozapine has been the standard treatment in this condition and is recognized unequivocally as being effective. However, clozapine is sometimes poorly tolerated and has the potential for severe toxicity. Partly as a result of this, other atypicals have recently been evaluated as treatments for refractory schizophrenia. In order to evaluate the evidence base relating to… 
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