Refractory iron deficiency anemia as the primary clinical manifestation of celiac disease.

@article{Mody2003RefractoryID,
  title={Refractory iron deficiency anemia as the primary clinical manifestation of celiac disease.},
  author={Rajen J Mody and Pamela I. Brown and Daniel S. Wechsler},
  journal={Journal of pediatric hematology/oncology},
  year={2003},
  volume={25 2},
  pages={
          169-72
        }
}
In the absence of dietary insufficiency, iron deficiency is usually caused by chronic blood loss or intestinal malabsorption. Celiac disease is one of the most common causes of intestinal malabsorption during childhood, and its association with insulin-dependent diabetes mellitus has been previously reported. Here the authors describe an otherwise asymptomatic diabetic adolescent boy with iron deficiency anemia that was not responsive to oral iron therapy. A diagnosis of celiac disease was made… 
View on PubMed
doi.org
49 Citations
Highly Influential Citations
1
Background Citations
13

49 Citations

The prevalence of celiac disease in children with iron-deficiency anemia.
TLDR
Screening of celiac disease by anti-tissue transglutaminase antibody should be done as a routine investigation in children with iron-deficiency anemia, and biopsy should be recommended in patients withIron-deficient anemia who have positive celiac Disease serology.
Hematologic manifestations of celiac disease
TLDR
The highest risk is for enteropathy associated T- cell lymphoma (EATL), an aggressive lymphoma with poor prognosis, however an increased risk for B-cell lymphomas and extraintestinal lymphomas has been described.
Extraintestinal Manifestations of Celiac Disease and Associated Disorders
TLDR
In several associated diseases, an adequate adherence to a gluten-free diet may slow their evolution, especially if implemented at an early stage, as well as in type-1 diabetes mellitus, thyroid diseases, and malignancy.
Subclinical celiac disease in children: refractory iron deficiency as the sole presentation.
TLDR
The experience of a pediatric gastroenterology outpatient clinic attended by 63 CD patients, in 9 of whom refractory iron deficiency was the sole presentation at the time of diagnosis, shows that iron deficiency is quite common during childhood and often anticipated in certain ages such as infancy and adolescence.
Hematologic manifestations of celiac disease.
TLDR
Patients with celiac disease are at increased risk of being diagnosed with lymphoma, especially of the T-cell type, and the risk is highest for enteropathy-type T- cell lymphoma (ETL) and B-cell lymphoma of the gut, but extraintestinal lymphomas can also be seen.
Iron deficiency anemia.
  • S. F. Clark
  • Medicine
    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
  • 2008
TLDR
The prevalence of IDA related to confounding medical conditions will be described along with its diverse etiologies, and current diagnostic strategies that are inclusive of clinical presentation, biochemical tests, and differential diagnosis will be outlined, followed by a discussion of treatment modalities and future research recommendations.
Refractory iron-deficiency anemia and gluten intolerance - Response to gluten-free diet.
TLDR
Age, anemia duration, number of transfusions,number of parenteral iron doses, and time on a gluten-free diet were compared according to the presence or absence of villous atrophy and HLA-DQ2/8 positivity, and no significant differences were found for any of the analyzed variables.
Pathogenesis and clinical manifestation of celiac disease: analysis of atypical symptoms
Celiac disease is defined as enteropathy occurring after ingestion of gluten from cereals in genetically predisposed individuals. Recently, after introduction of sensitive and specific screening…
Frequency, severity and type of anemia in children with classical celiac disease
TLDR
In anemic compared to non-anemic patients, there is a significantly higher BW deficit, while differences in other characteristics typical for this type of disease are not significant.
Celiac disease in patients with an affected member, type 1 diabetes, iron-deficiency, or osteoporosis?
TLDR
In conclusion, significant reservoirs of CD can be found in some at-risk groups, such as those with T1DM, family members, and referred patients with osteoporosis and anemia, where it is not clear what impact CD has on the quality of life of these individuals.
...
...

References

SHOWING 1-10 OF 37 REFERENCES
Iron-deficiency anemia as the sole manifestation of celiac disease
TLDR
A strict gluten-free diet led to an increase in serum iron, resolution of the anemia, and restitution of normal mucosal architecture, suggesting iron-deficiency anemia may be the lone manifestation of celiac disease.
Short Stature as the Major Manifestation of Celiac Disease in Older Children
TLDR
Close cooperation between pediatric endocrinology and gastroenterology clinics may be fruitful in the identification of celiac patients, especially in a group of older children with short stature, bone age retardation, and microcytic anemia.
Celiac disease and insulin-dependent diabetes mellitus
TLDR
The prevalence of biopsy-proven celiac disease among adult IDDM patients is eight times higher than that recently estimated for the general Italian population and the absence, except in one case, of gastrointestinal symptoms emphasizes the benefit of screening programs on populations at risk.
Subclinical coeliac disease is a frequent cause of iron-deficiency anaemia.
TLDR
Coeliac disease is a frequent cause of iron-deficiency anaemia, and antigliadin and antiendomysial antibody tests should be always performed in the diagnostic algorithm of anaemic patients.
[Diabetes and celiac disease].
TLDR
It is necessary to assess (at least once per two years) actively and on regular basis endogenous myosin and/or tissue transglutaminase antibodies in patients with type I diabetes.
The Prevalence and Clinical Characteristics of Celiac Disease in Juvenile Diabetes in Wisconsin
TLDR
The prevalence of celiac disease in children with juvenile diabetes in Wisconsin is at least 4.6%, which is comparable with European and Canadian studies, and the prevalence may be even higher because patients without villous atrophy may have latent Celiac disease.
The prevalence of celiac disease in at-risk groups of children in the United States.
Prospective evaluation of gastrointestinal tract in patients with iron-deficiency anemia
TLDR
It is concluded that the combination of colonoscopy and EGD identifies potential bleeding sources in most patients with IDA and in the absence of a potential bleeding lesion, small bowel biopsy at EGD is essential to diagnose celiac disease.
Identification of tissue transglutaminase as the autoantigen of celiac disease
TLDR
Tissue transglutaminase is identified as the unknown endomysial autoantigen of celiac disease, and gliadin is a preferred substrate for this enzyme, giving rise to novel antigenic epitopes.
Prevalence of Celiac Disease in Down Syndrome in the United States
TLDR
The prevalence of celiac disease in Down syndrome in the southeastern United States was 1 in 14 cases and antiendomysium antibody was a more sensitive screening test than antigliadin antibody.
...
...