Refractory depression in a patient with peripheral resistance to thyroid hormone (RTH) and the effect of triiodothyronine treatment

@article{Fardella2007RefractoryDI,
  title={Refractory depression in a patient with peripheral resistance to thyroid hormone (RTH) and the effect of triiodothyronine treatment},
  author={C. Fardella and Rocio Artigas and S. Gloger and M. Jim{\'e}nez and C. Carvajal and Paola M Krall and D. Quiroz and C. Campino and L. Mosso},
  journal={Endocrine},
  year={2007},
  volume={31},
  pages={272-278}
}
  • C. Fardella, Rocio Artigas, +6 authors L. Mosso
  • Published 2007
  • Medicine
  • Endocrine
  • We here described a 39-year-old woman with a severe chronic mood disorder, refractory to antidepressive therapy who showed a significant improvement after a self-prescription of high doses of liothyronine (T3). A modified Refetoff protocol was carried out to study the role of thyroid hormones on her clinical and biochemical responses. Depression severity was assessed by the HAM-D and MADRS Depression Rating Scales. Sequencing of Thyroid Receptors (TR) α1 and β1 genes was done. At the final… CONTINUE READING
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