Refractory atypical absence seizures in rat: a two hit model.

  title={Refractory atypical absence seizures in rat: a two hit model.},
  author={Irina Serbanescu and Miguel A. Cortez and Colin McKerlie and O. C. Snead},
  journal={Epilepsy research},
  volume={62 1},
Medically refractory seizure disorders in children usually have malignant neurodevelopmental outcomes and often are associated with the presence of congenital cortical dysplasias in the brain. To date, there are no animal models of these disorders by which to test hypotheses of pathogenesis or to screen novel drugs for antiepileptic activity. In rats, treatment with the antimitotic agent methylazoxymethanol acetate (MAM) on gestational day (G) 15 produces a neuronal migration disorder similar… CONTINUE READING