Refractory ascites: modulation of atrial natriuretic factor unresponsiveness by mannitol.

@article{Morali1992RefractoryAM,
  title={Refractory ascites: modulation of atrial natriuretic factor unresponsiveness by mannitol.},
  author={Gilles A. Morali and Sheldon W Tobe and Karl L. Skorecki and Laurie M Blendis},
  journal={Hepatology},
  year={1992},
  volume={16 1},
  pages={
          42-8
        }
}
We have previously shown that unresponsiveness to atrial natriuretic factor is a marker of the severity of ascites. The tubular mechanisms are unknown, but it seems that increased reabsorption of sodium proximal to the main site of action of atrial natriuretic factor (i.e., the inner medullary collecting duct) plays an important role. We attempted to decrease the proximal reabsorption of sodium with mannitol in patients unresponsive to atrial natriuretic factor. The results of mannitol in such… CONTINUE READING
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