Refractory Generalised Convulsive Status Epilepticus

@article{Klviinen2005RefractoryGC,
  title={Refractory Generalised Convulsive Status Epilepticus},
  author={Reetta K{\"a}lvi{\"a}inen and Kai J. Eriksson and Ilkka Parviainen},
  journal={CNS Drugs},
  year={2005},
  volume={19},
  pages={759-768}
}
The patient with status epilepticus has continuous or rapidly repeating seizures. Generalised convulsive status epilepticus (GCSE) is the most common form of the disorder and is a life-threatening condition that requires prompt medical management. Status epilepticus that does not respond to first-line benzodiazepines (lorazepam or diazepam) or to second-line antiepileptic drugs (phenytoin/fosphenytoin, phenobarbital or valproate) is usually considered refractory and requires more aggressive… 
Pharmacologic management of convulsive status epilepticus in childhood
The incidence of convulsive status epilepticus in children is approximately 20–50/100,000/year, and is an emergency requiring prompt medical intervention. Prolonged seizures lasting over 5 min are
Pharmacologic management of convulsive status epilepticus
The incidence of convulsive status epilepticus in children is approximately 20–50/100,000/year, and is an emergency requiring prompt medical intervention. Prolonged seizures lasting over 5 min are
Treatment of convulsive status epilepticus.
  • D. Treiman
  • Medicine
    International review of neurobiology
  • 2007
Continuous Infusion Antiepileptic Medications for Refractory Status Epilepticus: A Review for Nurses
TLDR
The purpose of this review was to summarize the available RSE literature focusing on CIV midazolam, pentobarbital, propofol, and ketamine, and to serve as a primer for nurses providing care to these patients.
Drugs Commonly Used to Treat Refractory Status Epilepticus in Clinical Practice
TLDR
Polytherapy may be considered a feasible choice for treating RSE when single-drug treatment for SE fails, and seven drugs that are commonly used to treat RSE are described.
The outcome of therapies in refractory and super-refractory convulsive status epilepticus and recommendations for therapy.
TLDR
An approach to therapy, divided into first-line, second-line and third-line therapy, is suggested on the basis of this outcome evaluation, noting the importance of treatments directed at the cause of the status epilepticus, and of supportive ITU care.
Therapie des Status epilepticus
TLDR
In patients with previous epilepsy a phase of increasing seizure activity (premonitory status) often heralds overt GCSE in which continuous epileptic activity prevails, leading to management of established GCSE prompts.
Status epilepticus in dogs and cats, part 2: treatment, monitoring, and prognosis.
TLDR
To discuss current anticonvulsant drug options and advances in treatment of status epilepticus (SE) and to review the prognosis associated with SE, a lack of evidence demonstrating clear benefit to the use of specific therapeutics for benzodiazepine-refractory SE is reviewed.
Pharmacological Management of Seizures and Status Epilepticus in Critically Ill Patients
TLDR
To prevent seizures and further complications in critically ill patients with acute neurological disease or injury, short-term seizure prophylaxis should be considered in certain patients.
Seizures and status epilepticus in the critically ill.
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