Refolding the engrailed homeodomain: structural basis for the accumulation of a folding intermediate.


The ultrafast folding pathway of the engrailed homeodomain has been exceptionally well characterized by experiment and simulation. Helices II and III of the three-helix bundle protein form the native helix-turn-helix motif as an on-pathway intermediate within a few microseconds. The slow step is then the proper docking of the helices in approximately 15 mus… (More)
DOI: 10.1016/j.bpj.2010.06.040


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