Reflux nephropathy and pregnancy.

@article{Jungers1987RefluxNA,
  title={Reflux nephropathy and pregnancy.},
  author={Paul Jungers},
  journal={Bailliere's clinical obstetrics and gynaecology},
  year={1987},
  volume={1 4},
  pages={955-69}
}
  • Paul Jungers
  • Published 1987 in Bailliere's clinical obstetrics and gynaecology
Reflux nephropathy is one of the renal diseases encountered most frequently in women of childbearing age. Patients with severe bilateral atrophy are the most likely to develop proteinuria, hypertension, focal glomerular sclerosis and progressive chronic renal failure, and those with persistent vesicoureteral reflux are the most likely to suffer recurrent pyelonephritic episodes. Often the disease is clinically latent and first manifests itself in pregnancy, mainly by urinary tract infection but… CONTINUE READING

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By contrast , when renal function is significantly impaired , that is in patients whose plasma creatinine concentration is in excess of 0.20 - 0.22 mmol l-1 at conception , especially when hypertension is also present , there is clearly a high risk of fetal growth retardation or intrauterine death .
Thus , women with reflux nephropathy should attempt to conceive before the plasma creatinine concentration has reached 0.20 mmol l-1 , and patients with values higher than these should be clearly advised of the high risk for both the pregnancy and the progression of the disease .
By contrast , when renal function is significantly impaired , that is in patients whose plasma creatinine concentration is in excess of 0.20 - 0.22 mmol l-1 at conception , especially when hypertension is also present , there is clearly a high risk of fetal growth retardation or intrauterine death .
Thus , women with reflux nephropathy should attempt to conceive before the plasma creatinine concentration has reached 0.20 mmol l-1 , and patients with values higher than these should be clearly advised of the high risk for both the pregnancy and the progression of the disease .
By contrast , when renal function is significantly impaired , that is in patients whose plasma creatinine concentration is in excess of 0.20 - 0.22 mmol l-1 at conception , especially when hypertension is also present , there is clearly a high risk of fetal growth retardation or intrauterine death .
Thus , women with reflux nephropathy should attempt to conceive before the plasma creatinine concentration has reached 0.20 mmol l-1 , and patients with values higher than these should be clearly advised of the high risk for both the pregnancy and the progression of the disease .
Often the disease is clinically latent and first manifests itself in pregnancy , mainly by urinary tract infection but also by proteinuria , hypertension , pre - eclampsia or renal failure .
By contrast , when renal function is significantly impaired , that is in patients whose plasma creatinine concentration is in excess of 0.20 - 0.22 mmol l-1 at conception , especially when hypertension is also present , there is clearly a high risk of fetal growth retardation or intrauterine death .
Thus , women with reflux nephropathy should attempt to conceive before the plasma creatinine concentration has reached 0.20 mmol l-1 , and patients with values higher than these should be clearly advised of the high risk for both the pregnancy and the progression of the disease .
Patients with severe bilateral atrophy are the most likely to develop proteinuria , hypertension , focal glomerular sclerosis and progressive chronic renal failure , and those with persistent vesicoureteral reflux are the most likely to suffer recurrent pyelonephritic episodes .
Moreover , there is a striking risk of rapid worsening of renal function and hypertension , with accelerated progression towards end - stage renal failure .
Patients with severe bilateral atrophy are the most likely to develop proteinuria , hypertension , focal glomerular sclerosis and progressive chronic renal failure , and those with persistent vesicoureteral reflux are the most likely to suffer recurrent pyelonephritic episodes .
Moreover , there is a striking risk of rapid worsening of renal function and hypertension , with accelerated progression towards end - stage renal failure .
Patients with severe bilateral atrophy are the most likely to develop proteinuria , hypertension , focal glomerular sclerosis and progressive chronic renal failure , and those with persistent vesicoureteral reflux are the most likely to suffer recurrent pyelonephritic episodes .
Moreover , there is a striking risk of rapid worsening of renal function and hypertension , with accelerated progression towards end - stage renal failure .
Moreover , there is a striking risk of rapid worsening of renal function and hypertension , with accelerated progression towards end - stage renal failure .
Patients with severe bilateral atrophy are the most likely to develop proteinuria , hypertension , focal glomerular sclerosis and progressive chronic renal failure , and those with persistent vesicoureteral reflux are the most likely to suffer recurrent pyelonephritic episodes .
Often the disease is clinically latent and first manifests itself in pregnancy , mainly by urinary tract infection but also by proteinuria , hypertension , pre - eclampsia or renal failure .
Moreover , there is a striking risk of rapid worsening of renal function and hypertension , with accelerated progression towards end - stage renal failure .
Patients with severe bilateral atrophy are the most likely to develop proteinuria , hypertension , focal glomerular sclerosis and progressive chronic renal failure , and those with persistent vesicoureteral reflux are the most likely to suffer recurrent pyelonephritic episodes .
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