Reflux-induced apoptosis of the esophageal mucosa is inhibited in Barrett's epithelium.

@article{Wetscher1998RefluxinducedAO,
  title={Reflux-induced apoptosis of the esophageal mucosa is inhibited in Barrett's epithelium.},
  author={Gerold J. Wetscher and Hubert G Schwelberger and Alexander Unger and Felix Albert Offner and Christoph Profanter and Katherine Glaser and Anton Klingler and Michael Gadenstaetter and Patricia Klinger},
  journal={American journal of surgery},
  year={1998},
  volume={176 6},
  pages={
          569-73
        }
}
BACKGROUND Apoptosis maintains cell homeostasis. Altered apoptosis is involved in carcinogenesis. It was our aim to investigate whether reflux esophagitis may alter apoptosis in the esophageal mucosa and whether antireflux surgery may restore normal apoptosis. METHODS Apoptosis was studied preoperatively and postoperatively in esophageal biopsies of 39 patients with various grades of reflux esophagitis and in Barrett's mucosa using the TUNEL method. Biopsies were also taken from lesions of… CONTINUE READING

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