Reflux, Barrett's oesophagus and adenocarcinoma: burning questions

  title={Reflux, Barrett's oesophagus and adenocarcinoma: burning questions},
  author={Christopher Paul Wild and Laura J. Hardie},
  journal={Nature Reviews Cancer},
The incidence of oesophageal adenocarcinoma is increasing rapidly in Western populations. Gastro-oesophageal reflux disease is a strong risk factor for both this tumour and the pre-cancerous lesion Barrett's oesophagus, but the underlying disease mechanisms remain unclear. Developing a better understanding of the aetiology and pathogenesis of Barrett's oesophagus, including the induction of DNA damage and genetic alterations, might provide opportunities for improved management of individuals… CONTINUE READING


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