Reflections on the total synthesis of natural products: Art, craft, logic, and the chiron approach

  title={Reflections on the total synthesis of natural products: Art, craft, logic, and the chiron approach},
  author={Stephen Hanessian},
  journal={Pure and Applied Chemistry},
  pages={1189 - 1204}
  • S. Hanessian
  • Published 1 January 1993
  • Chemistry
  • Pure and Applied Chemistry
The Chemical Synthesis of Tetrodoxin: An Ongoing Quest
This contribution reviews all the synthetic work on tetrodotoxin that has appeared in the literature through June 2011.
The enterprise of synthesis: from concept to practice.
A retrospective account of natural products synthesis adopting the Chiral Synthon (Chiron) Approach and spanning nearly 50 years of personal research activity is presented highlighting the interplay
Principles for Synthetic Efficiency and Expansion of the Field
Today, the field of natural product total synthesis, which was once a dominant sub‐discipline of organic chemistry, has lost its prime position. Even with the renaissance of natural products as drug
Syntheses of Asymmetrically Substituted Pyrans of Natural Origin
Apart from pyranoid carbohydrates, which are the most abundant natural products, there are plenty of secondary metabolites, which contain six membered oxygen heterocyclic ring constituents that are
Deaminative Arylation of Amino Acid-derived Pyridinium Salts.
A Suzuki-Miyaura cross-coupling of α-pyridinium esters and arylboroxines has been developed and Mechanistic studies support an alkyl radical intermediate, similar to other cross-Couplings of alkylpyrid inium salts.
Principles, Concepts and Strategies of Stereoselective Synthesis
The basic principles, concepts, and strategies of stereoselective synthesis needed to understand the stereochemistry of chiral drugs and natural products are defined in this chapter. Keywords:
Asymmetric catalysis: an enabling science.
  • B. Trost
  • Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
General themes for designing catalysts to effect asymmetric induction are helping to make this strategy more useful, in general, with the resultant effect of a marked enhancement of synthetic efficiency.


Computer-aided molecular design.
Two types of calculations that show special promise as design tools, the thermodynamic cycle-perturbation method and the Brownian reactive dynamics method, can be applied to calculate equilibrium and rate constants that describe many aspects of molecular recognition, stability, and reactivity.
Protective Groups in Organic Svnthesis, Wiley, N.Y
  • React., 28,
  • 1982
Academic Press, N.Y., 1, 1 1 1 (1984)
  • Taber in Topics i Stereochemistry,
  • 1984
avermectin Bla aglycone, see J.D
  • 1990