Reflections on the total synthesis of natural products: Art, craft, logic, and the chiron approach

@article{Hanessian1993ReflectionsOT,
  title={Reflections on the total synthesis of natural products: Art, craft, logic, and the chiron approach},
  author={S. Hanessian},
  journal={Pure and Applied Chemistry},
  year={1993},
  volume={65},
  pages={1189 - 1204}
}
  • S. Hanessian
  • Published 1993
  • Chemistry
  • Pure and Applied Chemistry
An overview is given of various strategies aimed at the total synthesis of natural products, with particular emphasis on some clinically important molecules. Of necessity, total synthesis must also incorporate the elements of absolute stereochemistry, and the ultimate objective of obtaining enantiomerically pure or enriched products. In this regard, the Chiron Approach which capitalizes on the recognition and eventual use of readily available, chiral non-racemic starting materials, has been… Expand
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References

SHOWING 1-4 OF 4 REFERENCES
Computer-aided molecular design.
avermectin Bla aglycone, see J.D
  • 1990
Academic Press, N.Y., 1, 1 1 1 (1984)
  • Taber in Topics i Stereochemistry,
  • 1984
Protective Groups in Organic Svnthesis, Wiley, N.Y
  • React., 28,
  • 1982