Reflections on the total synthesis of natural products: Art, craft, logic, and the chiron approach

@article{Hanessian1993ReflectionsOT,
  title={Reflections on the total synthesis of natural products: Art, craft, logic, and the chiron approach},
  author={Stephen Hanessian},
  journal={Pure and Applied Chemistry},
  year={1993},
  volume={65},
  pages={1189 - 1204}
}
  • S. Hanessian
  • Published 1 January 1993
  • Chemistry
  • Pure and Applied Chemistry
Abstract 
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Deaminative Arylation of Amino Acid-derived Pyridinium Salts.
TLDR
A Suzuki-Miyaura cross-coupling of α-pyridinium esters and arylboroxines has been developed and Mechanistic studies support an alkyl radical intermediate, similar to other cross-Couplings of alkylpyrid inium salts.
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Asymmetric catalysis: an enabling science.
  • B. Trost
  • Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
General themes for designing catalysts to effect asymmetric induction are helping to make this strategy more useful, in general, with the resultant effect of a marked enhancement of synthetic efficiency.
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