Reflections on Twenty-Five Years of Annexin Research

@inproceedings{Creutz2002ReflectionsOT,
  title={Reflections on Twenty-Five Years of Annexin Research},
  author={Carl E. Creutz},
  year={2002}
}
This is a personal account of the discovery of synexin (annexin VII) in 1977, along with some selected observations on the development of the annexin field since that time. 

Figures from this paper

Parasite annexins – New molecules with potential for drug and vaccine development
TLDR
An overview of novel annexins from parasitic organisms is presented, and a predicted additional secondary structure element found in many parasite annexins that may confer unique functional properties and present a specific antigenic epitope for use as a vaccine is described.
In vitro induction of apoptosis, necrosis and genotoxicity by cosmetic preservatives: application of flow cytometry as a complementary analysis by NRU
TLDR
Flow cytometry is a more sophisticated methodology for understanding the cytotoxic mechanisms of cosmetic preservatives and can be used to complement the NRU, and results showed that PE, PP, MP and BA have similar cytot toxic mechanisms.
Protection of the membrane permeability barrier by annexins.
TLDR
It was determined that in the presence of calcium, annexin A5 reduced the level of baseline leakage from vesicles and reduced or reversed damage due to arachidonic acid, lysophosphatidic acid,Lysoph phosphatidylcholine, diacyl glycerol, monoacylglycersol, spermidine, amyloid-β, amyin, and osmotic shock.
73 PROTEOMIC ANALYSIS OF THE MAJOR CELLULAR PROTEINS OF BOVINE TROPHECTODERM CELL LINES DERIVED FROM IVP, PARTHENOGENETIC, AND NUCLEAR TRANSFER EMBRYOS: REDUCED EXPRESSION OF ANNEXIN I IN NUCLEAR TRANSFER-DERIVED CELL LINES
TLDR
Because annexins I and II are abundant in the placenta and have functions important to the main- tenance of placentation, the down-regulation of the annexin genes in the cultured NT trophectoderm may be related to the frequent failures of NT pregnancies.
Proteomic analysis of the major cellular proteins of bovine trophectoderm cell lines derived from IVP, parthenogenetic and nuclear transfer embryos: Reduced expression of annexins I and II in nuclear transfer-derived cell lines.
TLDR
Because annexins I and II are abundant in the placenta and have functions important to the maintenance of placentation, the down-regulation of the annexin genes in the cultured NT trophectoderm may be related to the frequent failures of NT pregnancies.

References

SHOWING 1-10 OF 143 REFERENCES
Annexins: a novel family of calcium- and membrane-binding proteins in search of a function.
Although the annexins have been extensively studied and much detailed structural information is available, their in vivo function has yet to be established.
Interaction of viruses with annexins: a potential therapeutic target?
  • E. Depla
  • Biology, Medicine
    Current opinion in investigational drugs
  • 2000
TLDR
This review elaborates on the known interactions of annexins with some viral pathogens of man and describes some structural considerations and potential functions of these annexins before going into a more detailed analysis of the viral interactions themselves.
The annexinopathies: a new category of diseases.
  • J. Rand
  • Biology, Medicine
    Biochimica et biophysica acta
  • 2000
The annexins are a family of highly homologous phospholipid binding proteins, which share a four-domain structure, with one member of the family - annexin VI - having a duplication consisting of
The annexins and exocytosis.
The annexins are a group of homologous proteins that bind phospholipids in the presence of calcium. They may provide a major pathway for communication between cellular membranes and their cytoplasmic
Platelet annexin V: the ins and outs
TLDR
This review distinguishes between the potential intracellular role of annexin V in platelet activation, and the uses of annexIn V in particular to detect apoptosis.
Annexins—New family of Ca2+-regulated-phospholipid binding protein
TLDR
A model is proposed for the tertiary structure of a common calcium and phospholipid binding domain and two of these proteins (calpactins) also bind F-actin and are substrates for tyrosine kinases.
Selective secretion of annexin 1, a protein without a signal sequence, by the human prostate gland.
TLDR
The human prostate gland selectively secretes high concentrations of annexin 1 and a proteolytic cleavage product, des1-29-annexin 1, into seminal plasma, which appears to involve a highly selective mechanism that does not involve targeting to the endoplasmic reticulum by a hydrophobic signal sequence.
Annexins : molecular structure to cellular function
TLDR
In this volume, crystallographic and other high-resolution structural data are integrated into issues related to annexin function, while the overall focus is on research with a more cellular emphasis.
The in vivo role of annexin VII (synexin): characterization of an annexin VII-deficient Dictyostelium mutant indicates an involvement in Ca(2+)-regulated processes.
TLDR
The data suggest that annexin VII is not required for membrane fusion events but rather contributes to proper Ca2+ homeostasis in the cell.
Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure.
TLDR
The basic mechanisms underlying the loss of membrane asymmetry during apoptosis are described and the novel annexin V-binding assay is discussed, an extension to the current available methods.
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