Refining the role for adult stem cells as cancer cells of origin.

  title={Refining the role for adult stem cells as cancer cells of origin.},
  author={Andrew C. White and William E Lowry},
  journal={Trends in cell biology},
  volume={25 1},
Significant progress has been made to identify the cells at the foundation of tumorigenesis, the cancer cell of origin (CCO). The majority of data points towards resident adult stem cells (ASCs) or primitive progenitors as the CCO for those cancers studied, highlighting the importance of stem cells not only as propagators but also as initiators of cancer. Recent data suggest tumor initiation at the CCOs can be regulated through both intrinsic and extrinsic signals and that the identity of the… CONTINUE READING
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