Refining the predictive pursuit endophenotype in schizophrenia.

  title={Refining the predictive pursuit endophenotype in schizophrenia.},
  author={L. Elliot Hong and Kathleen A. Turano and Hugh B. O'Neill and Lei Hao and Ikwunga Wonodi and Robert Patrick McMahon and Amie R Elliott and Gunvant K. Thaker},
  journal={Biological psychiatry},
  volume={63 5},
BACKGROUND To utilize fully a schizophrenia endophenotype in gene search and subsequent neurobiological studies, it is critical that the precise underlying physiologic deficit is identified. Abnormality in smooth pursuit eye movements is one of the endophenotypes of schizophrenia. The precise nature of the abnormality is unknown. Previous work has shown a reduced predictive pursuit response to a briefly masked (i.e., invisible) moving object in schizophrenia. However, the overt awareness of… CONTINUE READING

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