Refining the high-dose streptozotocin-induced diabetic non-human primate model: an evaluation of risk factors and outcomes.


In preparation for islet transplantation, diabetes was induced using streptozotocin (STZ) in non-human primates ranging from juveniles to adults with diverse body types: we studied the process with respect to the diabetic state and emergence of adverse events (AEs) and their severity, and identified risk factors for clinical and laboratory AEs… (More)
DOI: 10.1258/ebm.2011.011064