Refining the diagnosis of Huntington disease: the PREDICT-HD study

  title={Refining the diagnosis of Huntington disease: the PREDICT-HD study},
  author={Kevin M. Biglan and Ying Zhang and Jeffrey D. Long and Michael D. Geschwind and Gail A. Kang and Annie Killoran and Wenjing Lu and E. A. McCusker and James A. Mills and Lynn A Raymond and Claudia Testa and Joanne M Wojcieszek and Jane S. Paulsen},
  booktitle={Front. Aging Neurosci.},
Participants with the gene expansion for Huntington disease (HD) but not yet diagnosed were evaluated annually. Unidimensional diagnosis (UD) was a motor diagnosis defined as a diagnostic confidence level (DCL) of 4 (unequivocal motor signs, ≥99% confidence) on the standardized motor exam of the Unified Huntington Disease Rating Scale (UHDRS). Multidimensional diagnosis (MD) was defined as answering yes on Question 80 (Q80) of the UHDRS, ≥99% confidence of manifest HD based on the entire UHDRS… CONTINUE READING
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