Refining the analysis of a whole genome linkage disequilibrium association map: the United Kingdom results.

@article{Yeo2003RefiningTA,
  title={Refining the analysis of a whole genome linkage disequilibrium association map: the United Kingdom results.},
  author={Tai Wai Yeo and Richard H Roxburgh and Mel J. Maranian and Sara Singlehurst and Julia L Gray and Anke E Hensiek and Efrosini Setakis and Alastair D Compston and Stephen J Sawcer},
  journal={Journal of neuroimmunology},
  year={2003},
  volume={143 1-2},
  pages={53-9}
}
Individual genotyping of the 10 most promising markers identified in our previously reported screen for linkage disequilibrium (LD) in multiple sclerosis identified a number of effects which confound the analysis and are of general importance in the interpretation of results obtained using microsatellite markers typed in pooled DNA. In order to identify and characterise these effects, we individually genotyped 529 promising markers in 16 trio families. We then devised adapting factors, which… CONTINUE READING

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