Refining retinoic acid stimulation for osteogenic differentiation of murine adipose-derived adult stromal cells.

@article{Wan2007RefiningRA,
  title={Refining retinoic acid stimulation for osteogenic differentiation of murine adipose-derived adult stromal cells.},
  author={Derrick C Wan and Matthew T Siedhoff and Matthew D. Kwan and Randall P Nacamuli and Benjamin M. Wu and Michael Thornton Longaker},
  journal={Tissue engineering},
  year={2007},
  volume={13 7},
  pages={1623-31}
}
Murine adipose-derived adult stromal cells (ADAS) seeded onto appropriate scaffolds and pre-incubated with retinoic acid have been shown to generate in vivo bone rapidly. Prompt resorption ensues, however, as a result of osteoclastogenesis, likely secondary to retinoic acid carryover. In this study, we determined the effects of abbreviated retinoic acid exposure on ADAS osteogenic differentiation. Histological staining and gene expression analysis revealed that longer retinoic acid exposure… CONTINUE READING

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